Summary Text

SUMMARY: First diagnosed with myeloma October 2011. Recruited onto clinical trial Myeloma X11 (Lenalidomide) at Bristol Oncology and Haematology Centre. First High Dose Therapy and Stem Cell Transplant (HDT&SCT) in July 2012. On maintenance until June 2017. June 2018 recruited onto Myeloma XII trial (Ixazomib). December 2018 Second HDT&SCT. On maintenance until February 2020. August 2020 Commenced treatment involving Daratumumab. April 2021 relapsed. June 2021 recruited onto Cartitude 4 clinical trial and infused with CAR-T cells in October 2021. My own immune system is now fighting the cancer . I am exceedingly fortunate.


Wednesday, 20 March 2019

March 2019 - Great News

The weekend marked the 100th day after my stem cell transplant.  In order for me to be randomised for the next phase of the Myeloma XII trial, it was necessary last week for me to attend the BHOC for tests - yet another Bone Marrow Biopsy (my 6th I think), blood tests, urine test etc.  Following the blood tests in particular, I was phoned by the Trials Nurse to give me the fantastic news that yes, my paraprotein level qualified me for the next phase, and that I had been randomised to receive maintenance treatment.  It was maintenance treatment within the Myeloma XI trial that had benefited me so much.  I could not have wished for a better result now.

Yesterday, then, I attended clinic and saw the senior haematology consultant whereupon I was prescribed the necessary medications for the first of two consolidation cycles (each of 28 days).  The drugs involved are the same as I received at the start of the trial and include the trial drug, Ixazomib, with Thalidomide and Dexamethasone.  The latter two drugs gave me some side effects but the end result will, I'm sure, be worth it.  After the two consolidation cycles I will only need to take Ixazomib thereafter.  This drug is developing something of a positive reputation and would seem to be by far my best hope at the moment.

On non-medical subjects, Spring has finally arrived.  The increased temperature has finally enabled me to do some work on Brabinger (my Mazda MX5 !)

The daffodils had not really waited for spring but our magnolia is now putting on a magnificent show despite having been shaken badly during last week's storm Gareth.

Perhaps the very best indicator of spring is the primrose and we are blessed with many (perhaps reflecting the somewhat wild nature of our garden!

For me this spring has brought the emergence from winter and also the fantastic news about my myeloma treatment.  I feel truly refreshed !

The beautiful spring came; and when Nature resumes
her loveliness, the human soul is apt to revive also.
Harriet Ann Jacobs

KBO
Stephen